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About: http://data.cimple.eu/news-article/be3b792c175d9d71e9f0e49e16994c389ac4910836cbbff7d1a8f030 Goto Sponge NotDistinct Permalink

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rdf:type	schema:NewsArticle
schema:articleBody	Swiss pharmaceutical giant Roche said Thursday that it is planning to test whether a mix of its arthritis drug tocilizumab and Gilead's antiviral drug remdesivir could treat severe cases of COVID-19 effectively. Roche said in a statement that it had joined forces with Gilead for a global phase III clinical trial evaluating the safety and efficacy of using tocilizumab -- sold under the brand names Actemra and RoAcemtra -- combined with remdesivir in hospitalised patients with severe COVID-19 pneumonia. The clinical trial is due to begin in early June with approximately 450 patients participating in the United States, Canada and Europe, Roche said, adding that the randomised study would evaluate the drugs' efficiency compared to a placebo. Remdesivir has shown promise in a completed study and a separate trial is under way on tocilizumab's potential against the disease, but Roche said there were indications that mixing the two could be more effective. "We believe that combining an antiviral with an immune modulator could potentially be an effective approach to treating patients with severe disease," Levi Garraway, Roche's Chief Medical Officer and head of global product development, said in a statement. "We're pleased to partner with Gilead to determine whether combining these medicines could potentially help more patients during this pandemic," he said. A large US study published last week showed that remdesivir, initially developed against Ebola, helped severely ill COVID-19 patients who required supplemental oxygen, and accelerated their recovery. The United States and Japan have already authorised emergency use of the drug, and Europe is considering following suit. An ongoing French study has meanwhile indicated that tocilizumab, commonly used to treat rheumatoid arthritis, might help prevent extreme inflammation in people gravely ill with the novel coronavirus. Researchers believe the drug could help stave off a state of heightened immune response known as cytokine storms -- where the reaction to a foreign body such as a disease or chemical creates acute inflammation. Roche said the final results of that trial were expected in the coming months. noo/nl/rjm/rl
schema:headline	Roche, Gilead to test drug cocktail against severe COVID-19
schema:mentions	Oxygen therapy Cocktail Immune response Hoffmann-La Roche Inflammation Physician Clinical trial Arthritis Antiviral drug Placebo Remdesivir Medication French language Pneumonia Ebola virus disease Switzerland Japan Canada European Union Pandemic United States Severe acute respiratory syndrome coronavirus 2 Foreign body Tocilizumab Cytokine Rheumatoid arthritis Gilead Sciences
schema:author	http://data.cimple.eu/organization/1f0054d541e000623a2c1e561a247c073ef6328e8be9ffafda7b3fcd
schema:datePublished	2020-05-28 (xsd:date)
http://data.cimple...sPoliticalLeaning	other political leaning
http://data.cimple...logy#hasSentiment	negative sentiment
http://data.cimple...readability_score	93 (xsd:integer)
http://data.cimple...tology#hasEmotion	happiness

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