About: http://data.cimple.eu/news-article/a8a527cf5d787dd5d902913653d05d4530ec4ec8a78f72f4919e702c

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About: http://data.cimple.eu/news-article/a8a527cf5d787dd5d902913653d05d4530ec4ec8a78f72f4919e702c Goto Sponge NotDistinct Permalink

An Entity of Type : schema:NewsArticle, within Data Space : data.cimple.eu associated with source document(s)

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rdf:type	schema:NewsArticle
schema:articleBody	A US government expert panel has formally recommended against using a drug combination promoted by President Donald Trump to fight the coronavirus, because of its potential harmful impact on the heart. The National Institutes of Health's COVID-19 Treatment Guidelines warned doctors not to use the malaria drug hydroxychloroquine in combination with the antibiotic azithromycin outside of clinical trials. Taken together, the medicines were "associated with QTc prolongation in patients with COVID-19," the panel said. The QTc is a measure of how fast the heart is electrically recharging for its next beat and slowing it down too much increases the risk of blackouts, seizures and cardiac arrest. The drug combination has been promoted by Trump, who tweeted last month that it had "a real chance to be one of the biggest game-changers in the history of medicine." As for using hydroxychloroquine on its own, the panel, which comprises leading doctors from around the country, said there was not enough evidence either way. It said the same of the investigational antiviral drug remdesivir which has shown early promise against the virus. A US government funded analysis of how American military veterans fared on hydroxychloroquine posted on a medical preprint site on Tuesday found the drug had no benefit against COVID-19 over standard care, and was in fact associated with more deaths. Hydroxychloroquine and a related compound chloroquine have been used for decades to treat malaria, as well as the autoimmune disorders lupus and rheumatoid arthritis. They have received significant attention during the novel coronavirus pandemic and have been shown in lab settings to block the virus from entering cells and prevent it from replicating. But "in vitro" promise often fails to translate into "in vivo" success in the pharmaceutical world. The correct answer can only be determined through very large, randomized clinical trials that assign patients to receive either the drug under investigation or a placebo. Several of these are underway, including notably in the United States, Europe, Canada and the United Kingdom. ia/jm
schema:headline	US govt experts warn against virus drug combo promoted by Trump
schema:mentions	Preprint Antimalarial medication Systemic lupus erythematosus Azithromycin Epileptic seizure Autoimmune disease Antiviral drug Placebo Remdesivir Medication Cardiac arrest Antibiotic Chloroquine Ebola virus disease Ia (cuneiform) Hydroxychloroquine Canada Pandemic United Kingdom United States Coronavirus Severe acute respiratory syndrome coronavirus 2 President of the United States Donald Trump Drug-induced QT prolongation Rheumatoid arthritis
schema:author	http://data.cimple.eu/organization/1f0054d541e000623a2c1e561a247c073ef6328e8be9ffafda7b3fcd
schema:datePublished	2020-04-22 (xsd:date)
http://data.cimple...sPoliticalLeaning	other political leaning
http://data.cimple...logy#hasSentiment	negative sentiment
http://data.cimple...readability_score	85 (xsd:integer)
http://data.cimple...entionsConspiracy	suppressed cures conspiracy theory

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